Quantum anthropology offers a fascinating new perspective on humanity, culture, and the world by considering the quantum nature of reality. This interdisciplinary exploration begins with a profound question: what is the source of creation in the world? Or, as physicists might ask: what underlies the formation and emergence of material objects? Quantum theory suggests that ‘zero-point fluctuations in the vacuum’—random, ambient, fluctuating energy even in the emptiest spaces—may hold the key. This invisible force is thought to drive the actualization of matter and entities in time and space. Interestingly, this concept resonates with the cultural philosophies of many Indigenous peoples, who often speak of a life-giving force, an original singularity, or a ‘Great Mystery’. These ancient ideas, deeply embedded in Indigenous arts and artefacts, reflect a similar understanding of creation and emergence. In this lecture, Radek Trnka and Radmila Lorencová explore the intriguing parallels between quantum physics and Indigenous cosmologies, seeking to illuminate how these seemingly distant ways of thinking converge on the mystery of creation.